Research Progress on <i>MTHFR</i> C677T and A1298C Gene Polymorphisms and Gastrointestinal Tumors

Tumours of the digestive system include a number malignant tumours such as oesophageal, gastric and colorectal cancers, which have highest incidence mortality rates in world. Their occurrence is related to variety factors, diet, environment genetics. As key enzyme process folate metabolism, MTHFR gene polymorphism plays an important role pathogenesis development gastrointestinal tumours. This paper provides brief review relationship between polymorphisms tumours, with view identifying genetic effects MTHFR, exploring tract developing more effective prevention treatment strategies.